For the study designs of the 100 top-cited articles, clinical study accounted for 47% including gastric cancer (n = 28), Hp (n = 2), ulcer (n = 5), gastritis (n = 3), GISTs (n = 0), gastric bypass (n = 2), and others (n = 7), followed by basic science research 23%, review 7%, guideline and consensus 5%, questionnaires and clarification 5%, epidemiologic research 5%, meta-analysis 2%, and others 6% (Figure 5). This evidence concerns the gene HP and gastritis.