A recent study [36] evaluated the presence of L1CAM in cyst fluid from glioblastoma and demonstrated high levels of L1CAM in the cyst fluid of glioblastoma, for the mean levels of L1CAM in tumor cyst fluid were significantly higher in glioblastoma than in CSF of control patients, indicating soluble L1CAM might represent a motility promoting molecule in glioma progression. Here, L1CAM is linked to central nervous system cancer.