Specifically, all the L1CAM positive cases were diffuse gliomas, include 36 cases of WHO II (26 astrocytomas and 10 oligodendrogliomas), 28 cases of WHO III (18 anaplastic astrocytomas and 10 anaplastic oligodendrogliomas), and 45 cases of WHO IV (glioblastoma/GBM). Here, L1CAM is linked to astrocytoma (excluding glioblastoma).