Based on the evidence that miR-223 is especially increased in sputum supernatant of neutrophilic asthma patients compared to healthy controls and eosinophilic asthma patients (22), we suggest that miR-223 acts as a modulator to limit PARP-1 expression, controlling eosinophilic, and neutrophilic responses in asthma. Here, PARP1 is linked to asthma.