In two PDAC mouse models, pharmacologic blockade of PI3Kγ with the selective inhibitor TG100-115 reprogrammed TAMs to stimulate CD8+ T cell-mediated tumor suppression and inhibited tumor cell metastasis and desmoplasia, a fibrotic phenotype associated with TAMs and poor therapeutic efficacy (Kaneda et al., 2016a). Here, CD8A is linked to neoplasm.