Biochanin A (5,7-dihydroxy-4′-methoxy-isoflavone), an isoflavone most commonly found in legumes as red clover (Trifolium pratense), which acts as a natural modulator of the estrogen receptor (ER) α and ERβ, is able to enhance the transcriptional pathways physiologically activated by estrogens and inhibited during human pathological conditions, as osteoporosis in postmenopausal women (Joannou et al., 1995; Brynin, 2002; Setchell et al., 2002; Somjen et al., 2005; Yu et al., 2019). Here, ESR2 is linked to osteoporosis.