For one, experiments on colon cancer transformation indicated that the supernatant of SW480 human cancer cells and plasma-derived from patients with colon cancer can be transferred laterally to the healthy cells and transform cultured murine NIH-3T3 cells ontogenetically, as validated by quantification of K-ras-mutated sequences, p53 sequences, and beta-globin-encoding sequences (García-Olmo et al., 2010; Trejo-Becerril et al., 2012). Here, TP53 is linked to colonic neoplasm.