IRF5 and Hodgkins lymphoma: Likewise, derepresssion of an ERV, LOR1a LTR upstream of IRF5 transcription factor interferon regulatory factor 5 (IRF5), forms LTR-IRF5 chimeric transcripts, which derives IRF5 expression as a feature of malignancy in hodgkin lymphoma (Babaian et al., 2016).