The pooled CSF CXCL-13 sensitivity ranged from 89 to 97% and its pooled specificity was 96% (CI95% = 92–98%) in two meta-analyses (961 patients presenting Lyme neuroborreliosis and 3,282 controls) (cf. Figure 1) (Yang et al., 2017; Rupprecht et al., 2018). Here, CXCL13 is linked to Lyme disease.