However, in addition to its role as a positive regulator of antiviral cytokines, it is also reported as a negative regulator of NFκB (Benko et al., 2010) which is a hallmark for most virus infections and gatekeeper to several key actors in the innate immune response (Santoro et al., 2003; Zhao et al., 2015). Here, NFKB1 is linked to viral infectious disease.