Rouaud-Tinguely et al. demonstrated that supplementing epidermal skin equivalents with Poly I:C, TNF-α, IL-4, and IL-13 in the last 2 days of skin reconstruction, led to reproduction of the features of atopic dermatitis, including altered epidermal reconstruction and differentiation, enhanced thymic stromal lymphopoietin (TSLP) and IL-8 secretions (Rouaud-Tinguely et al., 2015). Here, IL4 is linked to atopic eczema.