They used the model to assess a variety of pulmonary diseases: (1) organoids derived from CF patient progenitors cells were used to examine the function of cystic fibrosis transmembrane conductance regulator (CFTR); (2) Lung tumoroid were made to enable assessment of histopathology, gene mutation and drug screening; and (3) infected organoids were shown to recapitulate the central diseases features of respiratory syncytial virus infection, showing that neutrophil recruitment occurred during co-culture (Sachs et al., 2019). This evidence concerns the gene CFTR and cystic fibrosis.