CD4 and infection: Follicular helper T cells (Tfh) that are CMV-specific for the glycoprotein pentameric complex (gH/gL/pUL128L) increase in numbers during the early phase of infection resulting in a rise in neutralizing antibodies, once the virus is cleared Tfh numbers decrease but glycoprotein specific Tfh CD4+ T cells are maintained over time (Bruno et al., 2016).