The kinetics of the development of an antibody response during primary HCMV infection in pregnant vs. non-pregnant women appear to be comparable (Revello et al., 2006), but pregnant women having a primary infection appear to have a decreased CD4+ lymphoproliferative response to CMV lysate and IL-2 production for at least 9 months after infection (Fornara et al., 2011). This evidence concerns the gene CD4 and cytomegalovirus infection.