Both P433V1 and K26V1 have agg4A and sepA but lack aar. A previous study showed an association between sepA and pediatric diarrhea cases compared to control patients (Boisen et al., 2012), and an agg4A+ Shiga toxin-producing E. coli (STEC)/EAEC hybrid strain that caused hemolytic uremic syndrome was described recently (Carbonari et al., 2019). The gene discussed is ESPL1; the disease is hemolytic-uremic syndrome.