In addition to the FASN and PPAR members, a membranous lipid with a sphingosine backbone, sphingolipid, as described earlier, is also involved in EMT induction by regulating sphingosine kinase 1 (SPHK1), which converts sphingosine into sphingosine 1-phosphate (S1P) (174, 175) in cancers. The gene discussed is SPHK1; the disease is cancer.