As predicted by in silico analyses using the SNPfold algorithm, the secondary structure of H19 was dramatically changed with rs2839698 C/T alleles, suggesting the rs2839698 variant might affect the susceptibility and prognosis of RCC by altering the secondary structure H19. It has been suggested that lncRNAs and miRNAs could negatively modulated each other by forming a reciprocal repression-regulatory loop (44, 45). The gene discussed is H19; the disease is renal cell carcinoma.