To elucidate CDCA2's oncogenic role in PCa, we further found that the loss of CDCA2 will increase the mRNA levels of some tumor suppressor genes, including RASSF1, KISS1, PML, and GADD45A. These tumor suppressor genes are involved in cell proliferation regulation and apoptosis (43–46); our findings will provide new insight for the mechanism of CDCA2 in tumorigenesis in addition to its regulation of CDKIs. The gene discussed is PML; the disease is posterior cortical atrophy.