To correlate the deleterious residues in the Rad50 HCC domain with zinc hook motif that was not found in the model, the structure of 181 residues (residue 585-766) that has been determined (PDB ID: 5GOX) independently was employed (Figs. 2C and 2D) for functional analysis. The gene discussed is RAD50; the disease is hepatocellular carcinoma.