TNF and hereditary disease: Furthermore, another in silico analysis performed using PolyPhen and SIFT on proteins related to several hereditary diseases such as glucose-6-phosphate dehydrogenase deficiency (G6PD), the receptor 1 for tumor necrosis factor-(TNFRSF1A), and familial mediterranean fever (MEFV) has concluded that some nsSNPs impact may also not be predicted deleterious to correspond to previous phenotypic effect (Tchernitchko, Goossens & Wajcman, 2004).