For example, a few mutations that is, S635G (H. sapiens), S679R, C680N, P682A, V683I (S. cerevisiae), V683R (M. musculus) and Q685S (S. cerevisiae) (Figs. 1B and 2D) located at the zinc hook domain (Table 2) and mutations on K22M (S. cerevisiae and M. musculus), R83I (S. cerevisiae and M. musculus), T191E, C221E and S106E (T. maritima) in the ATPase domain (Figs. 1B and 2B; Table 2) were experimentally validated to be deleterious; some causing embryonic lethality, growth defect, cancer predisposition, as well as hematopoietic and spermatogenic depletion in vivo (Bender et al., 2002). The gene discussed is DNAH8; the disease is cancer.