These results implied that cluster1 might be in a state with the highest anti-tumor characteristics (leukocyte fraction, cytotoxic CD8 T, Th1, Th2 cells and IFN-γ response) but high immunosuppressive features (Tregs, TAM-M0 and Th17 cells, proliferation and differentiation), cluster2 tended to be an immunosuppressive status, and cluster3 might be an immune resting state. This evidence concerns the gene CD8A and neoplasm.