CD4 and neoplasm: Cluster1 was rich in high infiltration activated adaptive immune cells (CD8 T cells, cytotoxic lymphocytes, T follicular helper cells), tumor-associated macrophage (TAM)-M0, plasma cells, and Tregs, while some innate and inactivated immune cells (resting mast cells, resting memory CD4 T cells, monocytes and neutrophils) and stromal cells (endothelial cells and fibroblasts) tended to decrease.