DSG1 and pemphigus: Hence, in this study, in order to evaluate the effectiveness of the ELISA assay as a follow-up tool for the management of pemphigus therapy, we sought to determine the titer of anti-desmoglein 1 and 3 auto-antibodies at the onset of the disease and during follow-up period (4th and 8th weeks after the initiation of treatment) and assess its association with the severity of the disease.