MTOR and colonic neoplasm: For example, AP promoted autophagy through the mTOR/AMPK/ULK1 pathway and could play an antidepressant effect [48], inhibited the growth of cisplatin-resistant colon cancer cells by inducing autophagy and apoptosis [49], and restored impairment of autophagy and downregulation of unfolded protein response regulatory proteins in keratinocytes exposed to ultraviolet B radiation [50].