The mechanisms by which diabetes induces the cardiac remodeling and cardiac dysfunction include increased collagen deposition with increased expression of transforming growth factor beta (TGF-β) and connective tissue growth factor (CTGF), transcription factors that drive collagen production, and in some cases increased activation of poly (ADP-ribose) polymerase 1 (PARP-1) [23]. This evidence concerns the gene CCN2 and diabetes mellitus.