In consistent with a previous report that MMP12 mRNA content significantly increased in the hearts of aging mice [17], we also found the protein levels of MMP12 increased in both FVB and OVE26 mice at 24 weeks, with a higher expression in OVE26 mice, implicating the role of T1D in senescence (Figure 5(a)). Here, MMP12 is linked to type 1 diabetes mellitus.