IL17A and osteoarthritis: It is worth mentioning the reduction in the secretion of two other interleukins, IL-17 and IL-23, that have been found in osteoarthritis joints which also cause destructive proteases and induction of the synthesis of NO [30], in addition to being considered those which play crucial roles in the induction of local inflammation and cartilage destruction diseases such as rheumatoid arthritis [34].