AGT and cardiac hypertrophy: Nox proteins are also involved in angiotensin-II-induced cardiac hypertrophy: it has been proposed that puerarin, an isoflavonoid, and polydatin, a resveratrol glucoside, have antioxidative and cardioprotective effects because they suppress angiotensin II-induced cardiac hypertrophy by inhibiting Nox-induced superoxide generation in murine cultured cardiomyocytes [68, 69].