Relevant to this concept, Cao et al. reported that stachydrine, a major constituent of Leonurus heterophyllus Sweet, can inhibit hypertrophy by decreasing angiotensin II-induced excessive autophagy and Nox2 activity in H9c2 cardiomyocytes and can ameliorate transverse aortic constriction-induced cardiac hypertrophy and excessive autophagy in Wistar rats in vivo [130]. The gene discussed is AGT; the disease is cardiac hypertrophy.