MAPK3 and cardiac hypertrophy: Similarly, allicin, a compound that exhibits antimicrobial, antioxidant, and antiproliferative activity, protects cardiac function and prevents the development of cardiac hypertrophy, both in vitro and in vitro, by suppressing NADPH oxidase activity and ROS generation, as well as ROS-dependent ERK1/2, JNK1/2, and Akt signaling [124].