ACE and heart failure: Finally, other heart failure therapies, such as angiotensin-converting enzyme (ACE) inhibitors, have antioxidant effects, since they are able to ameliorate inflammatory processes in the vessel wall [235] and to prevent smooth muscle cell proliferation and activation of NADPH oxidase [235, 236]; they are usually used instead of hydralazine avoiding a thrice-a-day drug with many adverse side effects [237].