CASP3 and dilated cardiomyopathy: Moreover, CYP2E1 is an important gene in the pathogenesis of dilated cardiomyopathy, since knockdown of CYP2E1 significantly ameliorates dilated and thin ventricles and dysfunctional contraction in cTnTR141W transgenic mice, a model of dilated cardiomyopathy, by reducing oxidative stress, activation of caspase-3 and caspase-9, release of cytochrome c, and apoptosis in the myocardium [76].