AKT1 and thyroid gland undifferentiated (anaplastic) carcinoma: Apatinib can inhibit tumor cell growth by blocking the VEGFR2/STAT3/Bcl-2 or Akt/GSK3β/angiogenin signaling pathways, suppressing tumor angiogenesis in osteosarcoma and anaplastic thyroid cancer, respectively [14, 15].