Rather than regulated serum lipids, RES attenuated Trimethylamine-N-Oxide (TMAO)-induced AS in ApoE−/− mice [32], ameliorated HFD induced AS in LDLR−/− mice [33], countered systemic lupus erythematosus-associated AS [34] and alleviated AS in atherosclerotic mice whose left carotid artery was partial ligated [35]. The gene discussed is APOE; the disease is systemic lupus erythematosus.