The center target genes, which might play an important role in CHD progression, were peroxisome proliferator activated receptor gamma (PPARG), matrix metalloproteinase 9 (MMP9), mitogen-activated protein kinase 8(MAPK8), mitogen-activated protein kinase 3(MAPK3), interleukin 6 (IL6), epidermal growth factor receptor (EGFR), vascular endothelial growth factor A (VEGFA), tumor necrosis factor (TNF), retinoid X receptor alpha (RXRA), and prostaglandin-endoperoxide synthase 2 (PTGS2). Here, MAPK8 is linked to coronary artery disorder.