This result was compared with those of 27 MGUS patients, 55 MM patients, and 22 healthy controls, demonstrating that the ratio of circulating Ang-1/Ang-2 was reduced in MM individuals with full-blown overt MM due to a biologically significant enhancement of Ang-2, but not in SMM or MGUS nonmalignant control subjects. The gene discussed is ANGPT2; the disease is Miyoshi myopathy.