MM cells adhere to bone marrow stromal cells (BMSCs) and trigger many pathways in the latter, resulting in the transcription and secretion of multiple cytokines such as interleukin-6 (IL-6), insulin-like growth factor-1 (ILGF-1), vascular endothelial growth factor (VEGF), and stromal cell-derived factor-1α (SDF-1α) which mediate MM cell growth, proliferation, survival, and drug resistance [13]. This evidence concerns the gene IGF1 and Miyoshi myopathy.