Furthermore, the effects of the IRGs on colon cancer development remain unclear, although cancer progression has been linked to CD1B (Lee et al., 2019), XCL1 (Chou et al., 2020; Tamura et al., 2020), PLCG1 (Wells and Grandis, 2003), NGF (Retamales-Ortega et al., 2017; Garrido et al., 2019), and OXTR (Ma et al., 2019). The gene discussed is PLCG1; the disease is colonic neoplasm.