In this context, tumor immune evasion is mediated by B-cells, CD4+ T-cells, CD8+ T-cells, neutrophils, macrophages, and dendritic cells (Liu and Cao, 2016; Spranger, 2016), which are closely related to tumorigenesis, progression, and metastasis (Berntsson et al., 2016; Liu and Cao, 2016; Väyrynen et al., 2016; Prizment et al., 2017; Van den Eynde et al., 2018). This evidence concerns the gene CD4 and neoplasm.