To date, CH variants in MSH6 have been identified in patients with high-grade glioma, non-Hodgkin's lymphoma, glioblastoma, medulloblastoma, AML, or colorectal cancer (Østergaard et al., 2005; Okkels et al., 2006; Scott et al., 2007; Peters et al., 2009; Bakry et al., 2014; Gröbner et al., 2018). This evidence concerns the gene C4B and glioblastoma.