For example, in AML, tumor suppressor genes that are known to harbor germline risk variants include BRIP1, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, PALB2, and SBDS (Sondka et al., 2018; Tate et al., 2019). Here, BRIP1 is linked to acute myeloid leukemia.