PITX2 and infection: The potential importance of rgs-CaM to host defense against geminivirus infection is highlighted by observations that over-expression in N. benthamiana plants leads to enhanced susceptibility to TGMV infection, while Arabidopsis plants containing an rgs-CaM T-DNA insertion mutation is are less susceptible to infection by CaLCuV and BCTV (Chung et al., 2014).