Interestingly, it has been reported that Arabidopsis SnRK1 can phosphorylate CaLCuV AC2 protein in vitro. In addition, a phosphomimic mutation in CaLCuV AC2 delayed symptom appearance in Arabidopsis and reduced viral DNA accumulation in protoplasts, suggesting that phosphorylation of AC2 by SnRK1 hinders the establishment of CaLCuV infection (Shen et al., 2014). This evidence concerns the gene ADCY2 and infection.