The results showed that Bregs (CD19+CD24+CD38+) were significantly higher in patients with active sarcoidosis as compared with patients with stable sarcoidosis (P = 0.037) and the healthy control group (P = 0.0091), while there was no significant difference when comparing stable sarcoidosis patients with the healthy control group (Figures 4A,D). This evidence concerns the gene CD38 and sarcoidosis.