Anti-inflammatory functions of GDF-15 are also apparent in a sepsis model, in which GDF-15 knockout mice mounted increased inflammatory responses to lipopolysaccharide (LPS), with increased expression of monocyte chemoattractant protein (MCP)-1, keratinocyte chemoattractant (KC)/mouse homolog of interleukin-8 (IL-8), IL-6, and TNF-α in both cardiac and renal tissues, finally leading to organ dysfunction. The gene discussed is GDF15; the disease is Sepsis.