Serum GDF-15 is significantly higher in patients with stage IV CRC compared to stage I-III and healthy individuals. Patients with liver metastasis have elevated serum levels of GDF-15. Disease recurrence is associated with increase of serum GDF-15 levels. Patients with higher serum GDF-15 had a trend to poorer tumor-specific survival. Here, GDF15 is linked to colorectal carcinoma.