Furthermore, many tumor cells release cytokines, chemokines, and growth factors that recruit and induce FOXP3+ Tregs, and induce MDSCs and macrophages to release Th2 cytokines such as Tgf-β, IL-4, IL-10, and IL-13 which suppress anti-tumor immunity (29, 34, 35). This evidence concerns the gene IL10 and neoplasm.