HS can present as a component of systemic autoinflammatory syndromes like pyoderma gangrenosum, acne, pyogenic arthritis, and HS (PAPASH) and pyoderma gangrenosum, acne, and HS (PASH), which are caused by mutations in PSTPIP1 (46, 47). The gene discussed is PSTPIP1; the disease is pyoderma gangrenosum.