To assess whether low Fli1 seen in SSc monocytes skews them toward differentiation into A-Mø, we next used Fli1-depleted THP1 cells, and treated them with 10 ng/ml phorbol-12-myristate-13-acetate (PMA) for 4 h to induce transdifferentiation into Mø (24). The gene discussed is FLI1; the disease is systemic sclerosis.