IL1B and neoplasm: However, 5-FU induces Nlrp3 inflammasome, which promotes the secretion of IL-1b by MDSCs and angiogenesis (136, 137), the RCC xenograft tumor-bearing mice received the combination treatment of 5-FU and anti-PD-L1 Abs has survival time and survival improvement, compared to those who received single treatment of 5-FU or anti-PD-L1 Abs (138).