Myeloid cells-derived VEGFA and FGF2 influenced ECs of tumor-associated blood vessels downregulating their expression and separating intercellular adhesion molecule 1 (ICAM1) and vascular cell adhesion molecule 1 (VCAM1), which may impose restrictions on T cell adhesion and extravasation, finally impairing T cell homing to tumors (59–61). Here, VCAM1 is linked to neoplasm.