TGFB1 and breast cancer: Using co-culture systems, the crosstalk between breast cancer cell and fibroblasts upregulated cytokines, such as IL-6 IL-8 and TGF-β and chemokines, such as CXCL1 and CXCL3, which are the molecules involving in the migration of cells and the induction epithelial-mesenchymal transition (EMT) (102).