SH3BP5 and infection: While mapping the full repertoire of epitopes bound by the polyclonal antibodies, or the full repertoire of functional activities of the antibodies, is beyond the scope of the current study, it is clear that the purified SAB-159 and SAB-159P antibodies exhibit extremely high titer neutralizing antibody levels and levels of neutralizing antibody in serum can predict protection against infection with HTNV and PUUV.