The results showed that the ferritin level was much higher in ALS patients compared with controls (MD = 70.48, 95% CI [51.41, 89.55], <i>p</i> < 0.00001), and the transferrin level was decreased in ALS patients compared with controls (SMD = -0.28, 95% CI [-0.38, -0.18], <i>p</i> < 0.00001), while there was no statistical difference in iron levels (SMD = 0.48, 95% CI [-0.07, 1.03], <i>p</i> = 0.09) between ALS patients and controls. Here, TF is linked to amyotrophic lateral sclerosis.