BACE1 and Alzheimer disease: BACE1, also called β-amyloid precursor protein cleaving enzyme 1 or β-secretase, is a transmembrane aspartyl protease that has gained significant attention as a crucial protease for the generation of the β-amyloid peptide, a crucial initiator in the pathogenesis of Alzheimer’s disease (AD) (Vassar et al., 1999).