It is speculated that porin, also termed a voltage-dependent anion-selective channel (VDAC), plays paramount roles in modulating pathogen infection in vectors, including bacteria and protozoa in ticks, and viruses in mosquitoes (Fongsaran et al., 2014; Alberdi et al., 2015; Rodríguez-Hernández et al., 2015; Jitobaom et al., 2016). Here, VDAC1 is linked to infection.