DUX4 and Facioscapulohumeral dystrophy: Using myocytes differentiated from induced pluripotent stem cells (iPSCs) derived from FSHD patients, Sasaki-Honda and collaborators (Sasaki-Honda et al., 2018) demonstrated that oxidative stress increased DUX4 expression by a DNA damage response signaling to the opened FSHD 4q35 region.