High levels of oxidative stress biomarkers, such as 4-HNE (Beal et al., 1997; LoGerfo et al., 2014), mitochondrial dysfunction (Shaw et al., 1995; Cutler et al., 2002), and, on the contrary, a downregulation of glutathione S-transferases (GSTs) (Curti et al., 1996; Simpson et al., 2004), peroxiredoxins (Kong and Xu, 1998), and nuclear factor erythroid 2-related factor 2 (Nrf2) (Wiedemann et al., 2002; Kato et al., 2005; Kirby et al., 2005; Usarek et al., 2005) were observed in ALS patients (Barber et al., 2006; Sarlette et al., 2008; Strong, 2010). Here, NFE2L2 is linked to amyotrophic lateral sclerosis.