In the last decade, genome-wide association studies identified two genes associated with sporadic and non-SOD1 familial ALS: RNA/DNA-binding proteins, 43 kDa transactive response (TAR) DNA-binding protein (TDP-43), and fused in sarcoma/translocated in liposarcoma (FUS/TLS) (Kato et al., 2000; Neumann et al., 2006; Guo et al., 2013; Milani et al., 2013). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.