Using isogenic controls of FSHD2 iPSCs in order to correct the SMCHD1 mutation, basal DUX4 expression was suppressed and heterochromatic markers at 4q35 were partially recovered, suggesting that oxidative stress could represent a risk factor in FSHD progression (Sasaki-Honda et al., 2018). This evidence concerns the gene SMCHD1 and Facioscapulohumeral dystrophy.