These evidences are in accordance with data provided from several labs describing PTX3 as a biomarker of endothelial dysfunctions, regulating nitric oxide, P-selectin, and fibroblast growth factor-2 production (Kotooka et al., 2008; Yasunaga et al., 2014; Carrizzo et al., 2015). Here, SELP is linked to endothelial dysfunction.