KCNE1 and Hypokalemia: That hypokalemia did not produce larger changes in ventricular repolarization is likely explained by the fact that repolarization of ventricular action potential in guinea pigs is more dependent on the IKs (KV7.1/KCNE1) current as compared to IKr (KV11.1) (O’Hara and Rudy, 2012).