KCNA1 and Ventricular arrhythmia: Moreover, one could speculate that the pure KV11.1-driven prolongation of the QTcH and Tp–Te interval observed caused by dofetilide was pro-arrhythmic, during hypokalemia, whereas a KCa2-driven prolongation of the QTcH with no effects on the Tp–Te interval appeared to protect the heart from ventricular arrhythmia.