TNFSF11 and osteoporosis: Currently, the most widely used anti-osteoporosis medications are anti-resorptive drugs, such as bisphosphonates (alendronate, risedronate, zoledronate, and ibandronate) and RANKL antibodies which are largely limited by the adverse events in high risk of gastrointestinal disturbance and infection respectively (Lorentzon, 2019).