The molecular bases of such effect were explained in a previous paper of the same group (García-Quiroz et al., 2012): calcitriol has an antiproliferative effect since it inhibits Kv10.1 (that modulates cell cycle and tumor progression) while astemizole is a blocker of Kv10.1 currents; the synergistic effects involve the downregulation of Cytochrome P 24A1 (CYP24A1), upregulation of Vitamin D Receptor (VDR) and Kv10.1 targeting. The gene discussed is KCNH1; the disease is neoplasm.