A paper published in 2003 (Abdul et al., 2003) and focused on Kv1.3 channels, demonstrated that potassium channel blockers such as dequalinium and amiodarone significantly reduced MCF-7 BC cells proliferation and increased the growth-inhibitory effects of the anti-estrogen drug tamoxifen on BC cell lines, also those derived from TNBC (MDA-MB231) (Abdul et al., 2003). This evidence concerns the gene KCNA3 and breast cancer.