INS and type 2 diabetes mellitus: exerted a favorable effect on insulin sensitivity during the 60 days period in type 2 diabetes mellitus patients (de Queiroz Mdo et al., 2012), but the single use of flour made from the rind of the yellow passion fruit over 56 days did not significantly improve glycemic control on type 2 diabetes patients (de Araújo et al., 2017).