Bhurtel et al. (2018) showed that MB protects dopaminergic neurons against MPTP-induced neurotoxicity by up-regulating brain-derived neurotrophic factor and Biju et al. (2018) showed that MB reduces motor deficits and olfactory dysfunction in a chronic MPTP-probenecid mouse model of Parkinson’s disease. Relevant to our study, Huang et al. (2018) investigated chronic oral MB treatment in a rat model of focal cerebral ischemia-reperfusion. This evidence concerns the gene BDNF and Cerebral ischemia.