APP and Alzheimer disease: The beneficial effects of senolytic intervention are attributed to either the selective killing of senescent astrocytes and microglia–not neurons-(Bussian et al., 2018) or the selective killing of neurons–not astrocytes-(Musi et al., 2018) in these tau models and to the selective killing of senescent OPCs –not astrocytes nor microglia-in the APP/PSEN1 AD model (Zhang et al., 2019).