For example, miR-146 expression was significantly upregulated in MG patients and accompanied by high TLR4, CD40, and CD80 expression levels in AChR-specific B cells (Lu et al., 2013), miR-15a appeared to be involved in the regulation of inflammatory cytokine expression in MG patients (Liu et al., 2016) and miR-125a-5p in the thymus may negatively regulate Foxp expression, leading to an imbalance in autoimmune regulation and MG pathogenesis (Li et al., 2016). The gene discussed is CD40; the disease is myasthenia gravis.