In addition, the PD-related LRRK2 mutation R1441C/G/H was demonstrated to impair PKA phosphorylation of a serine residue downstream of Arginine 1441 (S1444) within the Roc G-domain thereby disrupting its interaction with 14-3-3 proteins (Muda et al., 2014). The gene discussed is LRRK2; the disease is Parkinson disease.