LRRK2 and Parkinson disease: They have been found to interact with the phosphorylated residues pS910 and pS935 within the interdomain space between the predicted LRRK2 Ankyrin and LRR repeats whose phosphorylation levels correlate with LRRK2 kinase activity and are altered by PD-associated LRRK2 variants (Dzamko et al., 2010; Nichols et al., 2010).