It was reported that the anxiety disorder caused by alcohol withdrawal is related to a decrease in the expression of BDNF (Pandey et al., 2006), and micro-infusion of BDNF in the central nucleus of the amygdala not only reduces ethanol consumption but also reverses the anxiety induced by ethanol withdrawal (Pandey et al., 2006, 2008). Here, BDNF is linked to anxiety disorder.