LRRK2 and Parkinson disease: Interestingly, increased phosphorylated s1292 proximity ligation signal, indicative of increased LRRK2 kinase activity, has been reported in the nigral microglia of idiopathic PD cases as well rodents treated with rotenone, a pesticide used to model PD due to its selective degeneration of the nigrostriatal pathways (Di Maio et al., 2018).