LRRK2 and infection: However, it is important consider that a complete abolition of LRRK2 kinase activity in the peripheral immune system may have deleterious effects, with increased risk of infection and decreased pathogen control, as suggested by data from Lrrk2-KO models (Gardet et al., 2010; Zhang Q. et al., 2015; Liu et al., 2017; Wallings and Tansey, 2019).